ParkinsonCanadaV1, Main, Exploration, bibRecord, 003586

Enhancement of survival of stored dopaminergic cells and promotion of graft survival by exposure of human fetal nigral tissue to glial cell line-derived neurotrophic factor in patients with Parkinson's disease : Report of two cases and technical considerations

Identifieur interne : 003586 ( Main/Exploration ); précédent : 003585; suivant : 003587

Enhancement of survival of stored dopaminergic cells and promotion of graft survival by exposure of human fetal nigral tissue to glial cell line-derived neurotrophic factor in patients with Parkinson's disease : Report of two cases and technical considerations

Auteurs : I. Mendez [Canada] ; A. Dagher ; M. Hong ; A. Hebb ; P. Gaudet ; A. Law ; S. Weerasinghe ; D. King ; J. Desrosiers ; S. Darvesh ; T. Acorn ; H. Robertson

Source :

Journal of neurosurgery [ 0022-3085 ] ; 2000.

RBID : Pascal:00-0252924

Descripteurs français

Pascal (Inist)
- Parkinson maladie, Facteur GDNF, Neurone dopaminergique, Greffe, Mésencéphale, Antérieur, Etude cas, Traitement, Survie, Technique, Homme.
Wicri :
- topic : Homme.

English descriptors

KwdEn :
- Aged, Anterior, Brain Tissue Transplantation (pathology), Case study, Cell Count, Cell Line, Cell Survival, Dihydroxyphenylalanine (analogs & derivatives), Dopamine (secretion), Dopaminergic neuron, Feasibility Studies, Fetal Tissue Transplantation (pathology), Fluorine Radioisotopes, Follow-Up Studies, Glial cell line derived neurotrophic factor, Graft, Graft Survival, Human, Humans, Male, Mesencephalon (cytology), Mesencephalon (drug effects), Mesencephalon (embryology), Midbrain, Middle Aged, Nerve Growth Factor (therapeutic use), Neuroglia, Parkinson Disease (surgery), Parkinson disease, Putamen (surgery), Radiopharmaceuticals, Substantia Nigra (cytology), Substantia Nigra (drug effects), Substantia Nigra (embryology), Substantia Nigra (transplantation), Survival, Technique, Tissue Preservation, Tomography, Emission-Computed, Treatment, Treatment Outcome, Tyrosine 3-Monooxygenase (analysis).
MESH :
- chemical , analogs & derivatives : Dihydroxyphenylalanine.
- chemical , analysis : Tyrosine 3-Monooxygenase.
- cytology : Mesencephalon, Substantia Nigra.
- drug effects : Mesencephalon, Substantia Nigra.
- embryology : Mesencephalon, Substantia Nigra.
- pathology : Brain Tissue Transplantation, Fetal Tissue Transplantation.
- chemical , secretion : Dopamine.
- surgery : Parkinson Disease, Putamen.
- chemical , therapeutic use : Nerve Growth Factor.
- transplantation : Substantia Nigra.
- Aged, Cell Count, Cell Line, Cell Survival, Feasibility Studies, Fluorine Radioisotopes, Follow-Up Studies, Graft Survival, Humans, Male, Middle Aged, Neuroglia, Radiopharmaceuticals, Tissue Preservation, Tomography, Emission-Computed, Treatment Outcome.

Abstract

The authors have studied the ability of glial cell line-derived neurotrophic factor (GDNF) to promote survival of human fetal dopaminergic tissue after a storage period of 6 days and subsequent implantation into the human putamen. The results indicate that GDNF promotes survival of stored dopaminergic cells. Cells stored without GDNF had a 30.1% decrease in survival time compared with those exposed to GDNF. Two patients with Parkinson's disease received bilateral putaminal implants of fetal dopaminergic cells exposed to GDNF for 6 days and showed enhancement of graft survival as assessed by positron emission tomography scanning. A mean increase of 107% in putaminal fluoro-dopa uptake from baseline values was observed 12 months postgrafting.

Affiliations:

Le document en format XML

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<term>Anterior</term>
<term>Brain Tissue Transplantation (pathology)</term>
<term>Case study</term>
<term>Cell Count</term>
<term>Cell Line</term>
<term>Cell Survival</term>
<term>Dihydroxyphenylalanine (analogs & derivatives)</term>
<term>Dopamine (secretion)</term>
<term>Dopaminergic neuron</term>
<term>Feasibility Studies</term>
<term>Fetal Tissue Transplantation (pathology)</term>
<term>Fluorine Radioisotopes</term>
<term>Follow-Up Studies</term>
<term>Glial cell line derived neurotrophic factor</term>
<term>Graft</term>
<term>Graft Survival</term>
<term>Human</term>
<term>Humans</term>
<term>Male</term>
<term>Mesencephalon (cytology)</term>
<term>Mesencephalon (drug effects)</term>
<term>Mesencephalon (embryology)</term>
<term>Midbrain</term>
<term>Middle Aged</term>
<term>Nerve Growth Factor (therapeutic use)</term>
<term>Neuroglia</term>
<term>Parkinson Disease (surgery)</term>
<term>Parkinson disease</term>
<term>Putamen (surgery)</term>
<term>Radiopharmaceuticals</term>
<term>Substantia Nigra (cytology)</term>
<term>Substantia Nigra (drug effects)</term>
<term>Substantia Nigra (embryology)</term>
<term>Substantia Nigra (transplantation)</term>
<term>Survival</term>
<term>Technique</term>
<term>Tissue Preservation</term>
<term>Tomography, Emission-Computed</term>
<term>Treatment</term>
<term>Treatment Outcome</term>
<term>Tyrosine 3-Monooxygenase (analysis)</term>
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<keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Tyrosine 3-Monooxygenase</term>
</keywords>
<keywords scheme="MESH" qualifier="cytology" xml:lang="en"><term>Mesencephalon</term>
<term>Substantia Nigra</term>
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<term>Substantia Nigra</term>
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<term>Substantia Nigra</term>
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<term>Fetal Tissue Transplantation</term>
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<keywords scheme="MESH" type="chemical" qualifier="secretion" xml:lang="en"><term>Dopamine</term>
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<keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Parkinson Disease</term>
<term>Putamen</term>
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<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Nerve Growth Factor</term>
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<keywords scheme="MESH" qualifier="transplantation" xml:lang="en"><term>Substantia Nigra</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Cell Count</term>
<term>Cell Line</term>
<term>Cell Survival</term>
<term>Feasibility Studies</term>
<term>Fluorine Radioisotopes</term>
<term>Follow-Up Studies</term>
<term>Graft Survival</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Neuroglia</term>
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<front><div type="abstract" xml:lang="en">The authors have studied the ability of glial cell line-derived neurotrophic factor (GDNF) to promote survival of human fetal dopaminergic tissue after a storage period of 6 days and subsequent implantation into the human putamen. The results indicate that GDNF promotes survival of stored dopaminergic cells. Cells stored without GDNF had a 30.1% decrease in survival time compared with those exposed to GDNF. Two patients with Parkinson's disease received bilateral putaminal implants of fetal dopaminergic cells exposed to GDNF for 6 days and showed enhancement of graft survival as assessed by positron emission tomography scanning. A mean increase of 107% in putaminal fluoro-dopa uptake from baseline values was observed 12 months postgrafting.</div>
</front>
</TEI>
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<region><li>Québec</li>
</region>
<settlement><li>Montréal</li>
</settlement>
<orgName><li>Université McGill</li>
</orgName>
</list>
<tree><noCountry><name sortKey="Acorn, T" sort="Acorn, T" uniqKey="Acorn T" first="T." last="Acorn">T. Acorn</name>
<name sortKey="Dagher, A" sort="Dagher, A" uniqKey="Dagher A" first="A." last="Dagher">A. Dagher</name>
<name sortKey="Darvesh, S" sort="Darvesh, S" uniqKey="Darvesh S" first="S." last="Darvesh">S. Darvesh</name>
<name sortKey="Desrosiers, J" sort="Desrosiers, J" uniqKey="Desrosiers J" first="J." last="Desrosiers">J. Desrosiers</name>
<name sortKey="Gaudet, P" sort="Gaudet, P" uniqKey="Gaudet P" first="P." last="Gaudet">P. Gaudet</name>
<name sortKey="Hebb, A" sort="Hebb, A" uniqKey="Hebb A" first="A." last="Hebb">A. Hebb</name>
<name sortKey="Hong, M" sort="Hong, M" uniqKey="Hong M" first="M." last="Hong">M. Hong</name>
<name sortKey="King, D" sort="King, D" uniqKey="King D" first="D." last="King">D. King</name>
<name sortKey="Law, A" sort="Law, A" uniqKey="Law A" first="A." last="Law">A. Law</name>
<name sortKey="Robertson, H" sort="Robertson, H" uniqKey="Robertson H" first="H." last="Robertson">H. Robertson</name>
<name sortKey="Weerasinghe, S" sort="Weerasinghe, S" uniqKey="Weerasinghe S" first="S." last="Weerasinghe">S. Weerasinghe</name>
</noCountry>
<country name="Canada"><noRegion><name sortKey="Mendez, I" sort="Mendez, I" uniqKey="Mendez I" first="I." last="Mendez">I. Mendez</name>
</noRegion>
<name sortKey="Mendez, I" sort="Mendez, I" uniqKey="Mendez I" first="I." last="Mendez">I. Mendez</name>
</country>
</tree>
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</record>

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La maladie de Parkinson au Canada (serveur d'exploration)

Enhancement of survival of stored dopaminergic cells and promotion of graft survival by exposure of human fetal nigral tissue to glial cell line-derived neurotrophic factor in patients with Parkinson's disease : Report of two cases and technical considerations

Enhancement of survival of stored dopaminergic cells and promotion of graft survival by exposure of human fetal nigral tissue to glial cell line-derived neurotrophic factor in patients with Parkinson's disease : Report of two cases and technical considerations

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	La maladie de Parkinson au Canada (serveur d'exploration)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.